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Brdgt ([personal profile] brdgt) wrote2009-08-04 03:50 pm
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Science Tuesday - Domestication, Sleeping, and the Spleen.

Research Undermines Dog Domestication Theory
By NICHOLAS WADE, The New York Times, August 4, 2009

Few people spend their honeymoon catching and drawing blood from village dogs up and down Africa. But Ryan and Corin Boyko, two anthropologists at the University of California, Davis, chose this way to collect valuable genetic data that is casting a new light on the domestication of dogs.

The opportunity to combine love with science arose when Ryan’s brother Adam Boyko, a biologist at Cornell University, was discussing dog genetics with his professor, Carlos Bustamante. Dr. Bustamante, just back from a visit to Venezuela, remarked on how small the street dogs there were.

The two researchers wondered if the dogs carried a recently discovered gene that downsizes dogs from wolves and is found in all small dog breeds. Dr. Bustamante said the idea could be explored by collecting street dogs from up and down South America. Dr. Boyko, knowing his brother was planning a honeymoon in Africa but lacked the money to go far, proposed that the survey be done in Africa instead. “I paid for half their honeymoon,” Dr. Bustamante said.



Ryan and Corin Boyko collected 223 samples of village dog blood from Egypt, Uganda and Namibia. The small gene question has not yet been assessed, but their samples, reported in the current issue of the Proceedings of the National Academy of Sciences, have called into question a finding on the origin of dog domestication from wolves.

The origin is thought to be East Asia, based on a 2002 survey of both village dogs and breed dogs. But most of the village dogs in that survey came from East Asia, which could have tilted the outcome. The African village dogs turn out to have much the same amount of genetic diversity as those of East Asia. This is puzzling because the origin of a species is usually also the source of greatest genetic diversity.

The Boykos and Dr. Bustamante do not think dogs were domesticated in Africa — there are no wolves in Africa now, apart from the Ethiopian wolf — but they say the origin may not be East Asia. The issue is better addressed by looking just at village dogs, they think, and by excluding European breeds, which are mostly of recent origin.

They are now collecting samples from village dogs throughout the world — Ryan and Corin Boyko are at present catching dogs in New Guinea — in hope of tracing not just the place or places where dogs were first domesticated, but also the travels that dogs then took around the world with their masters.

The lack of any sharp gradient of genetic diversity between East Asian and African village dogs could mean that once domesticated, dogs spread very quickly from their point of origin. Another explanation, Dr. Boyko said, is that they originated at some point halfway between the two regions, like in the Caucasus mountains.

Robert Wayne, a biologist at the University of California, Los Angeles, said the new report “leaves in disarray” the thesis that dogs evolved in East Asia. But they could not have evolved in sub-Saharan Africa, which has no wolves, and “so must have evolved somewhere else, maybe in the Middle East,” Dr. Wayne said.

The solution to the origin of the dog will come from sampling wolves throughout the world as well as village dogs, Dr. Wayne said. A genome-scanning chip, similar to those developed for studying the human genome, has been developed for dogs. Dr. Wayne, working with Dr. Boyko and colleagues, has used the chip to scan wolf genomes. He said they were now working on a report that might resolve the current quandary as to where the first dogs originated.





Really? The Claim: Cold Temperatures Improve Sleep
By ANAHAD O’CONNOR, The New York Times, August 4, 2009

THE FACTS

Avoiding caffeine, sticking to a schedule and drinking a glass of warm milk are the usual tips for a good night’s rest. But the right room temperature can also play a crucial role.

Studies have found that in general, the optimal temperature for sleep is quite cool, around 60 to 68 degrees Fahrenheit. For some, temperatures that fall too far below or above this range can lead to restlessness.



Temperatures in this range, it seems, help facilitate the decrease in core body temperature that in turn initiates sleepiness. A growing number of studies are finding that temperature regulation plays a role in many cases of chronic insomnia. Researchers have shown, for example, that insomniacs tend to have a warmer core body temperature than normal sleepers just before bed, which leads to heightened arousal and a struggle to fall asleep as the body tries to reset its internal thermostat.

For normal sleepers, the drop in core temperature is marked by an increase in temperature in the hands and feet, as the blood vessels dilate and the body radiates heat. Studies show that for troubled sleepers, a cool room and a hot-water bottle placed at the feet, which rapidly dilates blood vessels, can push the internal thermostat to a better setting.

THE BOTTOM LINE

A slightly cool room and a lower core temperature are optimal for sleep.





Basics: Finally, the Spleen Gets Some Respect
By NATALIE ANGIER, The New York Times, August 4, 2009

As a confirmed crab apple who has often been compared to the splenetic Lucy Van Pelt character from Peanuts, I am gratified to learn that should my real spleen ever decide to vent in earnest, the outburst may just help save my life.

Scientists have discovered that the spleen, long consigned to the B-list of abdominal organs and known as much for its metaphoric as its physiological value, plays a more important role in the body’s defense system than anyone suspected.



Reporting in the current issue of the journal Science, researchers from Massachusetts General Hospital and Harvard Medical School describe studies showing that the spleen is a reservoir for huge numbers of immune cells called monocytes, and that in the event of a serious trauma to the body like a heart attack, gashing wound or microbial invasion, the spleen will disgorge those monocyte multitudes into the bloodstream to tackle the crisis.

“The parallel in military terms is a standing army,” said Matthias Nahrendorf, an author of the report. “You don’t want to have to recruit an entire fighting force from the ground up every time you need it.”

That researchers are only now discovering a major feature of a rather large organ they have been studying for at least 2,000 years demonstrates yet again that there is nothing so foreign as the place we call home.

“Often, if you come across something in the body that seems like a big deal, you think, ‘Why didn’t anybody check this before?’ ” Dr. Nahrendorf said. “But the more you learn, the more you realize that we’re just scratching on the surface of life. We don’t know the whole story about anything.”

Dr. Nahrendorf, with Filip K. Swirski, Mikael J. Pittet and a dozen other colleagues, performed the initial studies using mice, but the scientists suspect the results will apply to humans as well.

Ulrich H. von Andrian, an immunologist at Harvard Medical School who was not involved with the research, agreed that the findings were a surprise. “If one had to guess the source of these cells, one would have thought it likely that they were mobilized from the bone marrow rather than from the spleen,” he said. “The discovery adds another layer of complexity not previously associated with that organ.”

The latest work also sounds a cautionary note against underestimating a body part or dismissing it as vestigial, expendable or past its prime. In an accompanying essay, Ting Jia and Eric G. Pamer of Memorial Sloan-Kettering Cancer Center admit that “the spleen lacks the gravitas of neighboring organs” like the liver or the stomach “because we can survive without it.”

Spleens can rupture during contact sports, say, or in a motorcycle accident, at which point surgeons have no choice.

“It’s such a vascularized organ, and the risk of big-time hemorrhaging is so great, that if the spleen ruptures, it’s a surgical emergency,” said James N. George, a hematologist with the University of Oklahoma Health Sciences Center. “You have to remove it.”

The new findings in no way counter the necessity of excising a ruptured spleen, the researchers said, but they do suggest that the loss of the organ is more than a mere “inconvenience,” as it has often been depicted, and could help explain previous reports showing an enhanced risk of early death among people who have undergone splenectomies.

In one study that appeared in The Lancet in 1977, for example, researchers compared a group of 740 American veterans of World War II who had had their spleens removed as a result of battle injuries with a similar size sample of veterans who had suffered other war injuries but had kept their spleens. The splenectomized men, the researchers found, were twice as likely to die of cardiovascular disease as were the veterans in the control group. All of which means that despleening should be diligently guarded against, particularly among our little sports warriors, perhaps through the wearing of appropriate protective gear.

Researchers cite other cases in which organs were presumed to be so dispensable that they could be removed “prophylactically” — often with unfortunate outcomes. In recent years, for example, many older women undergoing hysterectomies have been advised to have their healthy ovaries removed at the same time, the rationale being: if you are past your childbearing years, why hang on to reproductive organs that might turn cancerous and kill you? Yet follow-up surveys have shown that women who underwent elective ovariectomy had a heightened risk of dying during a given study period, were more susceptible to heart disease and lung cancer and were twice as likely to develop Parkinson’s disease compared with women who had kept their ovaries. “Evolution has an edge on us,” Dr. Nahrendorf said. “I would be very careful about saying, ‘You don’t need this organ, get rid of it.’ ”

Another reason to esteem the spleen — a purplish, fist-size, five-ounce organ in the upper left quadrant of the abdominal cavity, just behind the stomach and under the diaphragm — is its illustrious medical and poetic history. Galen considered the spleen to be a source of one of the four bodily humors, specifically the black bile associated with irritable, melancholic cranks. In his poem, “Spleen,” Charles Baudelaire describes a young narrator so weary and despondent, unresponsive even to beautiful women and jesting men, that it is as if the “green waters of Lethe” fills his veins.

More recently, researchers determined that the spleen is like an elaborate wetlands, a Mississippi bayou for filtering and freshening the blood. In other organs, blood flows through an interconnected mesh of increasingly narrow arteries, veins and capillaries. The spleen, by contrast, has a so-called noncapillary circulatory system: as the blood flows in, it is dumped into puddle-like sinusoids, and to get back out it must squeeze between cells. That dumping and squeezing help filter out blood-borne parasites, aging blood cells too brittle for compression and the little oxidized pellets, the BB’s, with which red blood cells are often pocked. The spleen has often been called a graveyard for red blood cells, but it is more of a recycling center, for the iron and other components are plucked out of the cells and used to stock new hemoglobin cages.

Filtration, cannibalization, and now — serious monocyte cultivation. In the new study, the researchers began by looking at monocytes, the largest of the body’s white blood cells. “It was recognized that these cells are the major repair workers after a heart attack,” Dr. Nahrendorf said. “They remove dead muscle cells, they start rebuilding stable scar tissue, they stimulate the generation of new blood vessels.”

The cells make haste to cut and paste. “Within 24 hours after a myocardial infarction,” Dr. Nahrendorf said, “there are millions of monocytes” congregating around the broken heart. All of which would seem sensible, desirable, an excellent display of emergency preparedness, except that Dr. Nahrendorf and his principal colleagues were puzzled by one big unknown: Where did the rapid response team come from? The numbers circulating in the blood were simply too low. The researchers searched one organ after another, until they checked the spleen and found the monocytic mother lode. “The numbers there were huge, 10 times higher than what was in the bloodstream,” Dr. Nahrendorf said.

By the researchers’ reckoning, monocytes, like all blood cells, are born in the bone marrow and at some point migrate to the spleen, lured by cues yet to be identified. They sit and wait, a sessile bunch, but when aroused by such chemical signatures of damage as angiotensin, the cells surge forth without hesitation, a reaction the researchers hope someday to understand well enough to recapitulate at will. Hail to the chief, hail to the queen and hail to the monocytes residing in my spleen.


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